New Finding Could Lead to New Therapy for Multiple Sclerosis

August 1, 2012

Researchers at the Wayne State University School of Medicine, working with colleagues in Canada, have found that one or more substances produced by a type of immune cell in people with multiple sclerosis (MS) may play a role in the disease’s progression. The finding could lead to new targeted therapies for MS treatment.

B cells, said Robert Lisak, M.D., professor of neurology at Wayne State and lead author of the study, are a subset of lymphocytes (a type of circulating white blood cell) that mature to become plasma cells and produce proteins that serve as antibodies.

In patients with MS, the B cells seem to attack the brain and spinal cord. Researchers believe that there might be substances produced in the nervous system and the covering of the brain and spinal cord that attract the cells. Once the B cells are inside the central nervous system or brain, the cells secrete substances that damage the cells that produce protections.

“We think this is a very significant finding, particularly for the damage to the cerebral cortex seen in patients with MS, because those areas seem to be damaged by material spreading into the brain from the meninges, which are rich in B cells adjacent to the areas of brain damage,” Lisak said.

Do you have MS? NeuroTrials Research is conducting a research study to determine the efficacy of an investigational drug. Qualified participants receive all study-related exams and study drug at no cost. Compensation is available for time and travel. For more information, visit the study page or call us at 404-538-9284.


Huffington Post: Narcolepsy Remains Misunderstood and Underdiagnosed

July 20, 2012

Do you have narcolepsy? NeuroTrials Research and Atlanta School of Sleep Medicine CEO Dr. Russell Rosenberg discusses the misconceptions of narcolepsy that lead to underdiagnosis in his new article with the Huffington Post:

Narcolepsy usually begins in the teens or early 20s, and all of the symptoms do not emerge simultaneously. AWAKEN, an online survey conducted by Harris Interactive and sponsored by Jazz Pharmaceuticals, surveyed 1,000 adults from the general public, 300 primary care physicians, and 100 sleep specialists. The results found that symptoms associated with narcolepsy are not clearly recognized or understood, which may contribute to under or misdiagnosis of the disorder. 

Read full article.

Follow all Dr. Rosenberg’s posts.


NeuroTrials Conducting New RLS Research

July 18, 2012

More than 5 million Americans have been diagnosed with RLS and as many as 1 in 10 adults will experience symptoms of RLS in their lifetime. Atlanta-based NeuroTrials Research is currently conducting a clinical research study of an investigational medication to treat Restless Legs Syndrome (RLS).

The primary symptom of RLS is an irresistible urge to move limbs in order to relieve uncomfortable sensations which can be severe at times. While the disorder most commonly affects legs, it can also be experienced in the arms or torso. The constant need to move causes difficulty falling asleep or patterns of interrupted and restless sleep. Common symptoms include:

  • Creepy crawly sensations in the legs or arms, especially when at rest
  • Uncomfortable sensations may be relieved by rubbing or moving around
  • Discomfort begins in the early evening and intensifies as bedtime approaches

Currently, NeuroTrials is evaluating a medication for the treatment of RLS that is already approved as a treatment for pain in Europe. If approved, this drug may be an alternative to some of the existing medications that carry varying levels of side effects.

“RLS is an underdiagnosed condition for which we need better options and we are excited to continue moving RLS research forward,” said Dr. Michael Lacey, Lead Investigator of the study at NeuroTrials, “RLS does not discriminate – it can begin at any age – and current treatment options come with a variety of side effects.”

Nationally recognized physicians and researchers founded NeuroTrials over a decade ago. NeuroTrials continues to attract important Phase I-IV studies that impact the health and welfare of residents in Atlanta and nationwide.

NeuroTrials is currently enrolling participants for this study. Patients who are 18-70 with a history of RLS for over 6 months, can contact NeuroTrials at 404-851-9934 for more information. Qualified study participants receive free medical evaluations, treatment and are compensated for their time and travel.  For full study details, visit www.neurotrials.com/studies.aspx.

Interested participants can also follow NeuroTrials on Facebook (facebook.com/neurotrials) and Twitter (twitter.com/neurotrials) for real-time updates on all enrolling studies.


Two NeuroTrials Researchers Listed in Atlanta Magazine “Top Doctors”

June 28, 2012

At NeuroTrials, our research investigators are often top experts in their field. Atlanta Magazine has taken notice of some of our talented researchers, and TWO of our research physicians are honored in the 2012 Atlanta Magazine Top Doctors list. Congratulations!

Dr. Matthews Gwynn is co-medical director at NeuroTrials & was honored for his work with Atlanta Neurology. His areas of expertise include movement disorders & migraines.

 

 

Dr. James Kiely was also honored for his work with Atlanta Neurology, and is named as an expert in epilepsy. Dr. Kiely has worked as an investigator on several NeuroTrials studies.

 

 
Nationally recognized physicians and researchers founded NeuroTrials over a decade ago, and we are happy to continue that tradition. NeuroTrials continues to attract important Phase II-IV studies that impact the health and welfare of residents in Atlanta and nationwide. Keep up the great work!


Parents: Does Your Child Have Narcolepsy? A New Research Opportunity.

June 25, 2012

ImageAre your mornings a struggle because of your child’s narcolepsy?

Narcolepsy affects approximately 200,000 men, women and children in the United States alone, according to the National Institute of Sleep Disorders. However, these statistics may be too low, as many who suffer from narcolepsy are not getting diagnosed or treated – especially children.

One of the reasons it is so hard to diagnose narcolepsy in children is that the sleep-related problems may seem like a symptom of another disorder such as ADD or hyperactivity disorder. Many parents seek treatment for their child’s inability to stay awake or pay attention without realizing that they have an actual sleep disorder.

4 signs your child might have narcolepsy:

  1. Excessive daytime sleepiness.
  2. Cataplexy (floppy, ragdoll like movements) while awake.
  3. Sleep paralysis (unable to move once waking up).
  4. Hypnagogic hallucinations (repeated bad dreams your child cannot wake up from).

Has your child been diagnosed with narcolepsy?

NeuroTrials Research in Atlanta is conducting a new research study for excessive daytime sleepiness for children & teens with narcolepsy. Qualified participants will be compensated for time & travel.

Your child may qualify if he or she:

  • is 6-17 years of age
  • has a diagnosis of narcolepsy
  • is otherwise in general good health
  • suffers from excessive sleepiness associated with narcolepsy
  • has a parent or legal guardian available to attend all study visits
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For more information, call 404-851-9934 or visit the study landing page.


How Sleep Can Change Your Weight

May 31, 2012

Do you know from family history that you are a good candidate for weight problems? If you are genetically predisposed to being overweight, sleep could be the one area of a healthy lifestyle you are overlooking.

A new study analyzed the habits & body weights of 1,088 pairs of twins to conclude that individuals who sleep at least 9 hours per night have more control over their weight when paired with a healthy lifestyle than those who sleep less.

The researchers found that in the pairs of twins sleeping 9 or more hours per night, environmental factors such as diet & exercise accounted for 51% of BMI differences while genetics accounted for just 32%.

Among the twins who slept less than 7 hours per night, genes accounted for 70% of the differences in BMI while environmental factors accounted for just 4%.

From the study, we can conclude that getting an adequate amount of sleep lowers your genetic predisposition to weight gain, and allows healthy lifestyle choices to take effect in your body.

“The less you sleep, the more important genetic factors are to how much you weigh,” says lead author Nathaniel F. Watson, M.D., co-director of the University of Washington Medicine Sleep Center, in Seattle. “The longer you sleep, the greater the influence of environmental factors like meal composition and timing.”

While plenty of research exists to suggest a link between sleep and a high BMI, researchers could not rule out the possibility that genes are somewhat responsible for the link. By using sets of twins, both identical and fraternal, researchers were able to rule out complications caused by a myriad of different subjects with different backgrounds and risk levels.

Sleep deprivation can put stress on your body, making it impossible to shed extra pounds. Bodies interpret stress in the most basic terms, and slow down the burning of calories to keep you alert.

If you are working toward a beach body this summer, do not forget the impact sleep can have on your overall health. A healthy lifestyle regime should always include plenty of sleep.

If you are overweight and unable or unwilling to use a CPAP, you may qualify for a new research study evaluating the effect of an investigational weight loss drug, in combination with a personalized diet & exercise program, on the severity of obstructive sleep apnea (OSA). Click here to learn more.


Do You Have Sleep Apnea?

May 16, 2012

You may qualify for one of TWO new studies with NeuroTrials Research.

First, we currently need participants who are compliant with their prescribed CPAP treatment. The study will evaluate a positive airway pressure system against current CPAP treatments.

You may qualify for this study if you:

  • are 18-70 years old
  • are diagnosed with moderate to severe OSA
  • have been using a prescribed CPAP for at least 30 days
  • are otherwise in general good health

Qualified participants receive all study-related exams and study treatment at no cost. Compensation is available for time and travel. If you think you may qualify, call us at 404-851-9934 or visit neurotrials.com to get started today!

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COMING SOON- GET PRESCREENED TODAY

If you are NOT compliant with your prescribed CPAP treatment & are overweight, call NeuroTrials today to be prescreened for a study enrolling soon. NeuroTrials Research is evaluating the effect of an investigational weight loss drug, in combination with a personalized diet & exercise program, on the severity of obstructive sleep apnea (OSA).

 

You may qualify if you:

  • are 18-64
  • have a diagnosis of moderate to severe obstructive sleep apnea
  • are unable or unwilling to use a CPAP or other similar device
  • are overweight

All study-related care and study drug will be provided at no cost. Qualified participants will be compensated for time & travel.  Qualified participants receive all study-related exams and study treatment at no cost. Compensation is available for time and travel.

If you are interested in this study & meet the criteria, call us at 404-851-9934 or visit neurotrials.com to get started today!

DOWNLOAD A STUDY FLYER

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